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Year : 2019  |  Volume : 39  |  Issue : 2  |  Page : 257-262

Immunohistochemical expression of Bcl-2 in oral squamous cell carcinoma: a clinicopathological correlation

1 Department of Oral Pathology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
2 Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
MD Marwa M.A Zaki
Department of Pathology, Mansoura University, Mansoura, 35516
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/EGJP.EGJP_33_19

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Background Oral malignancy includes a group of neoplasms affecting any district of the oral cavity, salivary glands, and pharyngeal regions. Notwithstanding, this term has a tendency to be utilized conversely with oral squamous cell carcinoma (OSCC), which represents the most incessant of every oral neoplasm. It is evaluated that a greater than of 90% of oral neoplasm are OSCC malignancies. The Bcl-2 protein is the encoding result of Bcl-2 proto-oncogene. The overexpression of Bcl-2 protein assumes an imperative part in apoptosis protection in many tumors, including head and neck squamous cell carcinoma. Aim/objectives This study was conducted to scope and find out the possible role of Bcl-2 in the biological behavior of OSCC. Methods A total of 20 OSCC cases were immunohistochemically examined for expression of Bcl-2. Results and conclusions There was significant difference among grades of OSCC regarding Bcl-2 expression. A significant correlation between Bcl-2 expression and clinical staging, nodal infiltration, as well as distant metastasis was observed. We concluded that Bcl-2 may be used as a prognostic factor for OSCC and may aid in decisions on cancer diagnosis and therapy.

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