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ORIGINAL ARTICLE
Year : 2019  |  Volume : 39  |  Issue : 2  |  Page : 244-248

Endometrial biopsy in recurrent implantation failure: a histopathological and immunohistochemical study


1 Department of Pathology, Mansoura University, Mansoura, Egypt
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura, Mansoura, Egypt

Correspondence Address:
PhD Reham M Nagib
Department of Pathology, Mansoura University Hospitals, Elgomhouria Street, Mansoura City, Dakahlia 35111
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/EGJP.EGJP_30_19

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Background Recurrent implantation failure (RIF) may be related to a defect in endometrial receptivity. There is still lack of data regarding the effect of progesterone on endometrial receptivity, namely, expression of adhesion molecules. This study aimed at investigating the endometrium for histopathological changes and expression of E-cadherin and progesterone receptors (PR). Patients and methods This study was conducted on 40 endometrial biopsies from patients with RIF compared with 10 biopsies from age-matched control. Biopsies were examined for pathological changes and immunostained with PR and E-cadherin. Results There was a statistically significant reduction in stromal PR in cases compared with control, but no statistically significant difference was found in glandular PR expression. A significant reduction in glandular E-cadherin expression was evident in cases. Conclusion Endometrial biopsy may have a role in investigating women with RIF. Maintained stromal PR acts to allow expression of adhesion molecules like E-cadherin and opening of implantation window.


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