• Users Online: 122
  • Print this page
  • Email this page
Year : 2019  |  Volume : 39  |  Issue : 2  |  Page : 244-248

Endometrial biopsy in recurrent implantation failure: a histopathological and immunohistochemical study

1 Department of Pathology, Mansoura University, Mansoura, Egypt
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura, Mansoura, Egypt

Correspondence Address:
PhD Reham M Nagib
Department of Pathology, Mansoura University Hospitals, Elgomhouria Street, Mansoura City, Dakahlia 35111
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/EGJP.EGJP_30_19

Rights and Permissions

Background Recurrent implantation failure (RIF) may be related to a defect in endometrial receptivity. There is still lack of data regarding the effect of progesterone on endometrial receptivity, namely, expression of adhesion molecules. This study aimed at investigating the endometrium for histopathological changes and expression of E-cadherin and progesterone receptors (PR). Patients and methods This study was conducted on 40 endometrial biopsies from patients with RIF compared with 10 biopsies from age-matched control. Biopsies were examined for pathological changes and immunostained with PR and E-cadherin. Results There was a statistically significant reduction in stromal PR in cases compared with control, but no statistically significant difference was found in glandular PR expression. A significant reduction in glandular E-cadherin expression was evident in cases. Conclusion Endometrial biopsy may have a role in investigating women with RIF. Maintained stromal PR acts to allow expression of adhesion molecules like E-cadherin and opening of implantation window.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded66    
    Comments [Add]    

Recommend this journal