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Year : 2019  |  Volume : 39  |  Issue : 2  |  Page : 239-243

Double-expressor and triple-expressor lymphomas: are these prognostically distinct groups of diffuse large B-cell lymphoma?

1 Department of Pathology, Mansoura University, Mansoura, Egypt
2 Clinical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
PhD Reham M Nagib
Department of Pathology, Mansoura University Hospitals, Elgomhouria Street, Mansoura City, Dakahlia 35111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/EGJP.EGJP_29_19

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Background Diffuse large B-cell lymphomas (DLBCLs) are a heterogeneous group with variable prognosis. Double-expressor (DE) and triple-expressor (TE) lymphomas have emerged as uncommon indistinct subgroups of high-grade B-cell lymphomas that may have prognostic value. This study aimed at evaluating the role of immunohistochemistry (IHC) in the detection of DE and TE lymphomas as well as correlating them with clinicopathological parameters. Materials and methods This is a retrospective study conducted on 100 cases of DLBCL. Tissue microarray blocks were constructed and immunostained with antibodies for MYC, BCL2, BCL6, CD10, MUM1, and P53 to determine the germinal center, activated B cell, DE, and TE phenotypes. Results We have found a statistically significant correlation between both DE and TE lymphomas and reduced disease-free survival (P=0.03) as well as with nodal location (P=0.006). No statistically significant correlation was found with clinicopathological parameters such as age, sex, stage, international prognostic index score, or response to therapy. No statistically significant difference was found between DE and TE groups. Conclusion DE and TE lymphomas can be considered as poor prognostic subgroups of DLBCL associated with reduced disease-free survival. Our study stresses the value of immunohistochemistry in the detection of such adverse groups of DLBCL.

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